Thus the 2nd important issue is the special pharmacokinetics of the organism pregnant women, which may affect the pharmacodynamics of drugs, consequently increase or decrease the therapeutic effect and even cause side effects that are unlikely outside of pregnancy. Also modified pharmacokinetics can alter the usual effect of the drug, which can lead to undesirable effects on the fetus.

A special role in shaping the response of the fruit of the drugs belong to the placenta. There are 4 factors governing the "throughput" capacity of the placenta:

1. functional state of the placenta and its enzyme activity (about 100)

2. feature of blood flow through the placenta (affects infiltration and excretion of drugs)

3. feature of placental pharmacokinetics

4. psycho-emotional state of the mother.

On the blood supply to the pregnant uterus is influenced by many diseases: diabetes diabetes, hypertension, preeclampsia, eclampsia. Stressful situations long-term depression also have a negative impact on the blood supply to the pregnant uterus and placenta.

At placental pharmacokinetics affected by:

1. gestational

2. physico-chemical properties of drugs

3. speed of passing the placental barrier drug

4. duration of its

5. Features raspreleleniya drugs in tissues and organs of the fetus

6. biotransformation in the placenta and fetal organs

7. especially the elimination of the placenta.