Biotransformation drugs in the liver also varies, because decreases enzyme activity. However, remember that active substances the body can greatly affect the activity of liver enzymes. For example, elevated levels of Progesterone reduces the activity of enzymes. But in late pregnancy toxaemia their body is significantly increased level of 6-b-gidrokortizola, which entails an increased liver enzymes, and thus accelerates biotransformation of drugs in the liver.

excretion - this is another function of the organism, subject to change. On the one hand increases glomerular secretion, and on the other - is increasing and reabsorption in the tubules of the nephron. Therefore, elimination of many drugs and BAS and changes different direction. For example, the elimination of glucose increases, and excretion of ions Na ^{+ decreases. Increase speed filtering pregnant is relative, because their current plasma through the kidneys increases to about 100%, and the filtration rate only 70%. In addition, pregnant there is a tendency to alkalization of urine, and this leads to a change in the ionization molecule drugs, and, therefore, changes, and the number of reabsorbed drug.}