· Increases red cell mass by 18%, changing the size and shape, volume and weight

Regulator of erythropoiesis is erythropoietin. Placental lactogen (produced by the placenta) stimulates production of erythropoietin.Inhibitor are estrogens.

· Reduction of iron in the blood to the third semester 2-3 times

· Modified colloid-osmotic composition, biochemical changes composition, reduction of sodium, chlorine, potassium, magnesium, calcium, phosphate.

Developed metabolic acidosis and respiratory alkalosis.

· Violation of the protein composition of blood.

Reduced · oncotic blood pressure - reducing maintenance albumin to 25, total protein of blood to the end of pregnancy is reduced to 60-62 g / l, increased alpha and gamma globulin, albumin-globulin ratio decreases to 0.84;

· Decreased glucose, decreased glucose tolerance, decreased sensitivity to insulin. Pregnancy is diabetogennym factor.

As a result of lipolytic action of placental lactogen are increase in fatty acids, which are used for energy costs fetus.